A human protein that prevents hay fever, atopic dermatitis and other allergies has been discovered by a group of researchers. This breakthrough could pave the way for outstanding medicines that will treat these kinds of conditions.
A team at Tokyo’s University of Tsukuba, led by Professor Akira Shibuya, made the discovery. It was recently published by the scientific journal Nature Immunology.
The article explains that humans already carry the protein in their bodies. The group of researchers found the protein, named Allergen-1, on the outside area of mouse and human mast cells. Histamine and other allergy-causing substances are produced and released by these mast cells.
The group discovered that Allergen-1 prevents mast cells from sending signals to release histamine and similar substances. They also found that mice who were lacking in Allergen-1 were afflicted by extreme allergies.
Shibuya said that “If medicines enhancing Allergen-1 functions are developed, we can block the discharge of histamine and allergy-causing substances. We can then fundamentally suppress most allergies and provide sufferers with much better treatments.
Presently, there are medicines that keep the body from activating histamine and similar substances to treat those who suffer from allergies.
When the body’s immune system overreacts to protect the body from invading substances, allergies are activated. Some examples of allergies that often occur are allergic rhinitis and anaphylaxis caused by repeated bee stings.
The purpose of allergic reactions is to get rid of parasitic worms from the body by discharging extremely toxic substances like histamine. That is why these type of reactions can create such severe symptoms.