Monthly Archive for November, 2009

World’s first successful AIDS vaccine may prevent HIV in the future

Scientists and government leaders have now begun to explore how to figure out how to refine the world’s first effective AIDS vaccine. In a large study performed in Thailand, this new vaccine protected 1 in every 3 people from getting HIV.

This is great news but researchers are saying that it is not quite significant enough for instant use. This said, it is a milestone event in the 26 years since the AIDS virus originated. Until now, there were many scientists who feared that a successful vaccine would never be obtained because of recent setbacks. The U.N. agency UNAIDS and the World Health Organization said that the findings “instilled new hope” in the field, even though it will probably be years before a vaccine will be available on a large scale.

The study, which was performed by the Thailand Ministry of Public Health and sponsored by the U.S. Army, tested a combination of two vaccines in a “prime-boost” method. The first vaccine primes the immune system to attack HIV and the second makes the response stronger. Strains of HIV that are commonly found in Thailand were used in the study. Scientists emphasize that it is not yet known whether this type of vaccine will work against strains that are found in the U.S., Africa and other countries in the world.

The results of the study showed that new infections happened in 51 of the 8,197 given the vaccine and in 74 of the 8,198 who received fake shots. This came out to be a 31% lower risk of infection for the group with the real vaccine. Two of the infected participants who were administered the placebo actually died.

This was the very first time scientists have tried preventing HIV in the same way that they treat it – by using a combination approach. Two vaccines that work in different ways were used, which may explain why the method worked. Scientists said that neither vaccine was effective when they were given alone. The combo did reduce the risk of getting infected with HIV by more than 31% in the study of more than 16,000 volunteers from Thailand.

Scientists don’t know yet why the vaccine combination was successful. It was the Army’s suggestion to test the combination, according to Dr. Donald Francis, who is a former government scientist who helped pinpoint HIV as the cause of AIDS. He now leads the nonprofit group that holds the rights to AIDSVAX.

Aids advocates and scientists both agree that more research is needed but are very optimistic with this most recent vaccine. According to UNAIDS, every day there are 7,500 people in the world who are newly infected with HIV. It is estimated that the amount of people now living with the AIDS virus is estimated at a whopping 33 million.

First major study finds that Tylenol may interfere with vaccines

New research has indicated that giving babies Tylenol when they get childhood vaccinations to help prevent fever, may cause the shots to be less effective.

This is the first major study that links decreased immunity to the use of fever-reducing medicines. Even though the effect was diminutive, and most kids will still receive adequate protection from vaccines, the results do make an important argument against regularly giving Tylenol right after a vaccination according to the U.S. Centers for Disease Control and Prevention. An editorial was written along with the study, which was published in the October 16 issue of the British medical journal Lancet.

The study focused only on the preventive use of Tylenol – not whether it is safe to use after a fever develops.

Tylenol and its generic relative, acetaminophen, is routinely suggested to alleviate pain in babies. It is commonly given by parents right after or before a shot to help prevent a fever or fussiness, and some doctors even support this. The CDC’s vaccine advisory panel claims that it is a customary thing to do for children who are at high risk for seizures, which are often set off by fevers.

All this said, getting a fever after a vaccine isn’t really always a bad thing. It’s a natural response from the body. The new study has found that suppressing fever, particularly the very first time an infant gets a vaccine, appears to reduce the immune response and the number of protective antibodies that are created.

The study was carried out by military and government scientists in the Czech Republic and was performed at ten medical centers in that Eastern European country. Involved in the study were 459 healthy infants ranging in age from 9 to16 weeks old, who were receiving vaccines against polio, pneumonia, meningitis, whooping cough, tetanus, hepatitis and other early life diseases.

During the first day after the vaccination, half of the participants in the study were prescribed three doses of Calpol or paracetamol, which is a brand similar to Tylenol that is sold in Europe. Nothing but the vaccine was given to the other group.

The group that was given the drug showed lower rates of protective antibody levels from several vaccines. Another disturbing finding was that these lower levels stayed lower in this group, even after booster vaccines were given when the babies were 12 to 15 months old.

Then, the researchers analyzed 10 other vaccine studies and discovered evidence that using Tylenol to prevent fevers at the time of vaccination may lessen the immune system response rates. Similar results may or may not be true when using the tylenol or it’s generic to treat fevers after they develop.

Belgium based GlaxoSmithKline Biologicals sponsored the research. They make all the vaccines that were used in the study. Some authors have monetary ties with the company and Glaxo played a significant part in the results that were reported.

Many skeptical about new mammogram guidelines

Up until now, American women have always known to get an annual mammogram after age 40. Now, all of a sudden they are being told that this is not necessary until age 50 unless they have certain cancer risks. And who is telling them this? The U.S. Preventive Services Task Force made the startling announcement last week.

It is certainly understandable that this new advice has made many women feel uneasy. It seems like it has come out of nowhere with no warning. We all know someone who has been affected by breast cancer and many women under age 50 are now still alive because of a routine mammogram that discovered cancer early enough to be treated. Numerous women say they will ignore this advice and keep getting their mammograms as usual. On the flip side, there are those women who are excited, because they have been skeptical of the proficiency of the annual checkups for a long time.

Not only does the task force suggest women begin mammogram screening at age 5o, they are also saying that women age 50 to 74 get mammograms every two years instead of the standard yearly exams. Possibly the most surprising aspect to all these new guidelines is the almost unbelievable advice from doctors that women should stop doing self-checks on their breasts at home.

Since mammograms don’t cost too much for most women and are not invasive or painful, it will probably be difficult to change the minds of women who are cautious and are careful to get regular checkups in general. Many women who posted on nytimes.com said that they believe these new guidelines somehow stem from the debate on health care and are afraid that cost control was the culprit for this new scientific advice.

Experts are perplexed over increase in Type 1 diabetes in children

Usually when diabetes and children are mentioned in the same sentence,  Type 2 diabetes is what is being talked about. This is a condition that often occurs from being overweight or obese. This said, a new study indicates that Type 1, also called juvenile diabetes, should not be left out on the list of troubling diseases.

A current study from the British medical journal The Lancer has revealed that the amount of new cases of Type 1 diabetes in European children is continuously rising over what was expected. An evaluation of diabetes registries in 17 European countries revealed that Type 1 diabetes in children under age 15 is elevating at around 4% each year, and 4.3% for children ranging in age from 5 to 9. For some reason, girls in the younger age groups had higher rates of increase than the boys.

What is even more alarming is that the authors claimed that the frequency of new cases in children under age 5 is projected to double by the year 2020.

According to Dr. Dana Dabelea from the University of Colorado, a comparable movement is also happening in the U.S. In the same issue of The Lancet, mentioned earlier, she wrote “that the incidence of Type 1 diabetes may be increasing even faster than before.” In addition, she pointed out that the findings may draw attention to hazardous alterations in the environment in which modern children are being raised. Because of this, researchers are trying to pinpoint different things in the environment that may be to blame for the increase in diabetes cases, but no definite offenders have yet to be found.

Type 1 diabetes causes the body to make very little or no insulin, which is the hormone that regulates blood-sugar levels. Extremely high levels can trigger serious complications later in life in organs such as the eyes, heart and kidneys.

Some warning signs for Type 1 diabetes include intense hunger or thirst, urinating often, blurry vision and, in girls, having genital yeast infections often.

If a child is diagnosed with Type 1 diabetes, they will need to take insulin. This can be administered by injection or with specialized pens, infusers or pumps. Checking their blood sugar several times a day is something else they will have to master. Dealing with diabetes can be demanding for kids and their families of any age. Thankfully, breakthroughs in insulin delivery and monitoring have made it easier for children to have healthier and more normal lives.

For first time in 15 years, smoking rate has increased

For the very first time in about 15 years, cigarette smoking has moderately increased. This has upset health officials who were optimistic that the U.S. smoking rate had permanently moved below 20 percent.

According to a 2008 survey by the Centers for Disease Control and Prevention, slightly less than 21 percent of American adults claim that they smoke. Unfortunately, that is an increase from the previous year, which had only 19.8 percent claiming to be smokers. Also, it is the very first surge in adult smoking since 1994.

Since the increase is so minor, it might be seen as insignificant. For this reason, experts and health officials are saying that the rate is flat and not rising. This said, they are still upset about this troubling trend.

Vince Willmore, a spokesman for the Campaign for Tobacco-Free Kids, says that he believes they’ve hit a wall when it comes to decreasing adult smoking.  This campaign is a Washington-based research and advocacy organization.

Indoor smoking laws, cigarette taxes and Congress’ recent decision allowing the FDA to regulate tobacco have all contributed to smoking being conceived as a diminishing health hazard. Reductions in state tobacco control campaigns have compromised the positive steps that have been made towards reducing smoking. Some believe that tobacco companies are beginning to defeat rising obstacles.

Marketing cigarettes has consistently maintained and is now influencing kids and minorities by using flavored and menthol products, according to Dr. Clyde Yancy, who is the president of the American Heart Association. The industry has also been marking down cigarettes to compensate for tax increases. The average price of a pack of cigarettes has climbed 63 percent between 1997 and 2004. The price rose only 2 percent between 2004 and 2008, as adult smoking came down by 1 percent, according to industry sales data. Dr. Matthew McKenna, director of the CDC’s Office on Smoking and Health, says that adult smoking stayed at around 21 percent from 2004 to 2006 and then plummeted a complete percentage point in 2007.

The smoking rate for adults has decreased on and off since the middle of the 60s. During this time, about 2 out of every 5 American adults smoked. Currently it is 1 in 5, although federal goals for 2010 were aspiring to decrease the rate to 1 in 10.

The results from this survey, which was released November 12, were achieved from personal interviews of almost 22,00 adult Americans.

Sadly, cigarette smoking still remains as the leading preventable cause of death and illness in the United States.

UNC will soon test new flu drug

Around 6 patients at UNC Hospitals will be asked to test a new flu drug that has revealed positive results in treating severe cases but is currently still under investigation.

Although the clinical trial is about to begin, the anti-viral drug, Peramivir, was given an emergency O.K. towards the end of October by the U.S. Food and Drug Administration for hospitalized patients who are unable to take approved flu drugs like Tamiflu and Relenza.

Even if they don’t won’t to take part in the clinical trial, patients at UNC Hospitals will be able to get the new drug if they need it. Dr. Christopher Hurt, an infectious disease doctor and the site’s principal investigator, says that there will only be around six patients enrolled in the trial.

The drug, Peramivir, which was created by BioCryst Pharmaceuticals, is nearing government approval in Japan and has been through two sets of clinical trials in the United States.

Robert Bennett, executive director of business development and investor relations for BioCryst, says Peramivir works on the same principal as Tamiflu and Relenza by blocking an enzyme in flu viruses allowing it to multiply and spread. Because it is delivered in an intravenous drip, it is only being developed for hospital settings. Tamiflu comes as a pill and Relenza comes in the form of a nasal spray and both are available to patients through pharmacies as prescription drugs.

Dr. Christopher Hurt claims that the main advantage of Peramivir is when there are serious situations when the patient is too sick to swallow pills or is on a respirator and can’t inhale a drug. Also, he said, an intravenous method usually enters the bloodstream faster.

Stretching found to be beneficial to the heart

We all know that any aerobic exercise is good for your heart and research has revealed that it can delay the hardening of arteries that often occurs during the aging process. New discoveries now indicate that flexibility may also have a positive effect on keeping the arteries healthy.

Your risk for getting heart disease and stroke may be able to be predicted from a basic flexibility test. The American Physiological Society has published a new study giving evidence to the fact that with women and men over the age of 40, the capability to touch one’s toes can reveal the hardness of the arteries.

Hardening of the arteries may increase blood pressure and is a huge factor in the cause of heart disease. Past research has shown us that aerobic exercise can assist in slowing the process of stiffening arteries as we age. Now researchers are discovering that staying flexible is definitely beneficial to the arteries.